MOCHA-Nutrients-Fisicaro et al-raw data

Background: recently, the interest in the role of coffee intake on the occurrence and course of age-related neurological and neuropsychiatric disorders has provided inconclusive effect. Moreover, no study has evaluated the mocha coffee consumption in subjects with mild vascular cognitive impairment and late-onset depression. Methods: we assessed the association between different quantities of mocha coffee intake over the last year and cognitive and mood performance in a homogeneous sample of 300 non-demented elderly Italian subjects with subcortical ischemic vas-cular disease. Mini Mental State Examination (MMSE), Stroop Color-Word Interference test (Stroop T), 17-items Hamilton Depression Rating Scale (HDRS), Activities of Daily Living (ADL), and Instrumental ADL were the outcome measures. Results: MMSE, HDRS, and Stroop T were independently and significantly associated with coffee consumption, i.e., better scores with increasing intake. At the post-hoc analyses it was found that the group with a moderate intake (2 cups/day) had similar values compared to the heavily drinkers (≥3 cups/day), with the exception of MMSE. Conclusions: daily mocha coffee intake was associated with higher cognitive and mood status, with a significant dose-response association even with a moderate consumption. This might have translational implications for the identification of modifiable factors for vascular dementia and geriatric depression.

背景：近年来，有关咖啡摄入对年龄相关性神经及神经精神疾病的发生与病程的影响的研究结论仍尚无定论。此外，目前尚无研究针对轻度血管性认知障碍（mild vascular cognitive impairment）与迟发性抑郁（late-onset depression）患者的摩卡咖啡（mocha coffee）摄入情况展开评估。
方法：本研究纳入300例患有皮质下缺血性血管病（subcortical ischemic vascular disease）的意大利非痴呆老年同质性样本，评估了过去一年中不同剂量摩卡咖啡摄入与认知及情绪表现的关联。本研究的结局指标包括：简易精神状态检查表（Mini Mental State Examination, MMSE）、斯特鲁普色词干扰试验（Stroop Color-Word Interference Test, Stroop T）、17项汉密尔顿抑郁评定量表（17-item Hamilton Depression Rating Scale, HDRS）、日常生活活动能力（Activities of Daily Living, ADL）及工具性日常生活活动能力。
结果：MMSE、HDRS及Stroop T得分与咖啡摄入量呈独立且显著的正相关关系，即摄入越多，得分表现越好。事后分析显示，中等摄入量组（每日2杯）与大量饮用组（每日≥3杯）的各项指标值相近，但MMSE得分除外。
结论：每日摩卡咖啡摄入与更佳的认知及情绪状态相关，即使是中等摄入量也存在显著的剂量-反应关联。该研究结果可为识别血管性痴呆（vascular dementia）与老年期抑郁的可干预因素提供转化研究参考。