Mouse transcriptome of two genetic mutations of Grm1

We report two genetic mutations of GRM1, which are Grm1-S458A and Grm1b-R889W, identified from two natural short sleep families. The introduction of these mutations into mouse models also causes the mice to sleepless. Thus, these findings suggest GRM1 is another short sleep gene and highlight the essential roles of mGluRs in regulating human sleep. Hippocampus transcriptome of four wildtype (WT) mice, four Grm1-S458A mice, and four Grm1b-R889W mice.本研究报道了两例源自自然短睡眠家系的代谢型谷氨酸受体1基因（GRM1）基因突变，分别为Grm1-S458A与Grm1b-R889W。将上述突变引入小鼠模型后，可使小鼠呈现睡眠缩短表型。综上，本研究结果表明GRM1是又一个短睡眠相关基因，并凸显了代谢型谷氨酸受体（mGluRs）在调控人类睡眠过程中的关键作用。本数据集包含4只野生型（WT，wildtype）小鼠、4只Grm1-S458A突变型小鼠及4只Grm1b-R889W突变型小鼠的海马组织转录组数据。