Asymmetric Synthesis of Tri- and Tetrasubstituted Trifluoro­methyl Dihydro­pyranones from α‑Aroyloxy­aldehydes via NHC Redox Catalysis

The
asymmetric synthesis of tri- and tetra­substituted trifluoro­methyl
di­hydro­pyranones via an NHC-catalyzed redox process, introducing
methyl, benzyl, and aryl substituents to the C(5) position, is presented.
Their substrate-controlled derivatization into δ-lactones and
cyclic hemi­acetals containing stereo­genic trifluoro­methyl
groups is also described.

本论文介绍了通过NHC催化的氧化还原反应实现三氟甲基二氢吡喃酮的异相合成方法，该方法将甲基、苄基和芳基取代基引入至C(5)位置。同时，还描述了底物控制的衍生物转化为含有立体手性三氟甲基基团的δ-内酯和环状半乙醛的过程。