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Androgen Receptor Activation Attenuates PD-L1 Expression In Thyroid Cancer

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP304108
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Investigation into the AR binding sites showed AR activation impacts NF-kB signaling by increasing IkBa and preventing NF-kB translocation into the nucleus, reducing PD-L1 promoter activation. This study provides evidence of sex-homrone mediated regulatation of immune checkpoint molecules with potential ramification for immunotherapies.
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2021-02-03
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