Supporting data for "Study the therapeutic potential of transcutaneous auricular vagus nerve stimulation (TaVNS) for Alzheimer’s Disease (AD) in 5xFAD mouse model".

This is the supporting data for "Study the therapeutic potential of transcutaneous auricular vagus nerve stimulation (TaVNS) for Alzheimer’s Disease (AD) in 5xFAD mouse model". This study studied the therapeutic potential of TaVNS in AD, and the therapeutic effects were demonstrated in 5xFAD mouse mode, an AD rodent model.My study consisted of 3 studies: study 1 was to understand the pathologies displayed in the 5xFAD model; study 2 was to find out the optimal stimulation approach of TaVNS and see how it can affect the brain to achieve beneficial results. Study 3 was to validate the mechanism found in study 2. These studies include data from behavioral tests, immunohistochemistry studies, immunofluorescence studies, mass spectrometry studies, and gene expression RT-PCR studies. The dataset has included all the numerical raw and clean data of these tests and the statistical analysis. Overall, this study aim to test the hypothesis that TaVNS can be a therapeutic option for AD patients and the action mechanism is serotonin-dependent.<br><br>

本数据集为《经皮耳迷走神经刺激（transcutaneous auricular vagus nerve stimulation, TaVNS）用于5xFAD小鼠模型中阿尔茨海默病（Alzheimer’s Disease, AD）的治疗潜力研究》的配套数据。本研究探讨了TaVNS针对AD的治疗潜力，并在AD啮齿类动物模型——5xFAD小鼠模型中验证了其治疗效果。本研究包含三项子研究：子研究1旨在明确5xFAD模型所呈现的病理特征；子研究2旨在探寻TaVNS的最优刺激方案，并阐明其调控大脑以产生有益效果的作用路径；子研究3用于验证子研究2中揭示的作用机制。上述子研究涵盖了行为学实验、免疫组织化学实验、免疫荧光实验、质谱分析实验以及基因表达逆转录聚合酶链反应（reverse transcription polymerase chain reaction, RT-PCR）实验的相关数据。本数据集包含了上述所有实验的数值型原始数据与预处理后数据，以及对应的统计分析结果。综上，本研究旨在验证以下假说：TaVNS可作为AD患者的治疗选择，且其作用机制依赖于血清素（serotonin）通路。