To determine whether interference with mechanisms of vasoconstriction or inflammation would improve outcomes in ischemia reperfusion injury of the liver

Study was performed in groups of animals including healthy controls, ischemia reperfusion alone, and administration of drug followed by ischemia reperfusion. Samples from liver and isolated hepatocytes intact and one day after reperfusion were analyzed for gene expression in conjunction with other biological variables. Results indicated substantive alteration after drug intervention in multiple gene ontology groups and cellular events and processes after ischemia reperfusion.本研究以实验动物为研究对象，设置三类实验组别：健康对照组、单纯缺血再灌注组，以及先给予药物干预再进行缺血再灌注的给药处理组。分别采集完整肝脏组织与分离的完整肝细胞样本，以及上述两类样本在再灌注1天后的样本，结合其他生物学变量开展基因表达分析。结果显示，药物干预可使缺血再灌注后多个基因本体（Gene Ontology）分组及细胞事件与过程发生显著改变。