Gene Ontology enrichments (cellular components) of the RR and XDEL containing proteins.

Cellular component enrichment of the RR and XDEL motif. GO-term cellular component analysis was carried out using ProteinCenter software suite (Proxeon, Denmark) on proteins identified in the bioinformatic screen as containing the di-arginine motif in the first 25 residues. The analysis shows significant enrichment of the di-arginine motif in cytoplasmic membrane and membrane bound vesicles in comparison to XDEL. This is enriched in ER and organelle lumens when compared to the reference count of total proteins found in the GO database with identifications of ER and SR. No GO-term enrichment was observed for the KK cluster.