Hair follicle development: organogenesis - part 2 of 3

The hair follicle (HF) is the biological unit responsible for producing a single hair shaft. The follicles are arranged with concentric epithelial progenitor layers surrounding the dermal core, which is the dermal papilla (DP). Classically, the development of the follicle itself can be divided into three stages: [https://www.wikipathways.org/index.php/Pathway:WP2804 Induction], Organogenesis and [https://www.wikipathways.org/index.php/Pathway:WP2840 Cytodifferentiation]. Hair follicle development is a process dependent on epithelial-mesenchymal transitions orchestrated by many signaling pathways. Here we find one of three complex regulatory pathways assembled from a text mining approach portraying the development of this key mammal-specific structure.

毛囊（HF）是负责产生单个毛发轴的生物单元。毛囊由同心圆状的表皮祖细胞层围绕真皮核心排列，真皮核心即真皮乳头（DP）。传统上，毛囊的发育过程可分为三个阶段：[https://www.wikipathways.org/index.php/Pathway:WP2804 诱导]、[https://www.wikipathways.org/index.php/Pathway:WP2840 组织发生]以及[https://www.wikipathways.org/index.php/Pathway:WP2840 细胞分化]。毛囊的发育是一个依赖于上皮-间质转化，并由众多信号通路协调进行的复杂过程。本研究通过文本挖掘方法，揭示出由三个复杂调控通路组成的其中一条，描绘了这一关键哺乳动物特有结构的发育过程。