Association of C-Reactive Protein to Albumin Ratio in Patients with Isolated Coronary Artery Ectasia

Abstract Background Coronary artery ectasia (CAE) is defined as diffuse or localized dilatation of coronary artery lumen with a diameter of 1.5 to 2.0 times the adjacent normal coronary artery. The C-reactive protein to albumin ratio (CAR) is a useful inflammatory marker, which has been documented in coronary artery disease. Objective To analyze the association of CAE and CAR. Methods A case-control protocol was used in this study. We included 102 consecutive patients with isolated CAE without stenosis (56 men and 46 women; mean age 60.4 ± 8.8 years). The control subjects consisted of an equal number of sex and age matched patients with normal coronary arteries (55 men and 47 women; mean age 61.2 ± 9.1 years). Clinical features, laboratory findings, and medication use history were recorded. Student’s t test, Mann-Whitney U test, chi-square test, and linear and logistic regression analysis were performed. A 2-sided p < 0.05 was statistically considered significant. Results The CAR was increased in patients with CAE compared to the controls (32 and 16; p < 0.001). In addition, the CAR was found to be an independent predictor of CAE (OR = 2.202; 95% CI 1.184 – 5.365; p < 0.001). Conclusion In the present study, we determined that CAR levels were significantly higher in the CAE group than in the control group, and the CAR was significantly correlated with CAE. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

摘要 背景 冠状动脉扩张症（Coronary artery ectasia, CAE）定义为冠状动脉管腔弥漫性或局限性扩张，直径为相邻正常冠状动脉的1.5至2.0倍。C反应蛋白与白蛋白比值（C-reactive protein to albumin ratio, CAR）是一种实用的炎症标志物，已有研究证实其在冠状动脉疾病中的应用价值。目的 分析冠状动脉扩张症与C反应蛋白与白蛋白比值的相关性。方法 本研究采用病例对照研究设计。共纳入102例确诊为孤立性冠状动脉扩张症且无狭窄的连续患者（男性56例，女性46例；平均年龄60.4±8.8岁）。对照组为性别与年龄相匹配的冠状动脉正常患者，共102例（男性55例，女性47例；平均年龄61.2±9.1岁）。研究记录了受试者的临床特征、实验室检查结果及用药史。采用t检验（Student’s t test）、曼-惠特尼U检验（Mann-Whitney U test）、卡方检验（chi-square test）以及线性回归（linear regression）和逻辑回归（logistic regression）分析进行统计学分析，以双侧p<0.05作为统计学显著性判定标准。结果 与对照组相比，冠状动脉扩张症患者的C反应蛋白与白蛋白比值显著升高（分别为32和16；p<0.001）。此外，C反应蛋白与白蛋白比值可作为冠状动脉扩张症的独立预测因子（优势比OR=2.202；95%置信区间CI：1.184–5.365；p<0.001）。结论 本研究结果显示，冠状动脉扩张症组患者的C反应蛋白与白蛋白比值水平显著高于对照组，且该比值与冠状动脉扩张症显著相关。（《Arq Bras Cardiol》. 2020; [在线版] 预印刷，PP.0-0）