Sequencing of sorted CD11c cells from cortex and hippocampus

As sentinels for the immune system, MG also detect “danger” signals (pathogenic or traumatic insult), become activated, produce pro-inflammatory cytokines, and recruit monocytes and dendritic cells to the site of damage through a breached blood brain barrier or via brain lymphatics. Failure to effectively resolve MG activation can be problematic and lead to chronic inflammation, a condition proposed to underlie CNS pathophysiology in heritable brain disorders and age-related neurodegenerative and cognitive decline. We show that APOBEC1-mediated RNA editing occurs within microglia and is key to maintaining their resting status.