FAIRsharing record for: Patient Derived Xenograft Minimum Information

This FAIRsharing record describes: Patients-derived tumor xenograft (PDX) mouse models are an important oncology research platform to study tumor evolution, drug response and personalised medicine approaches. We identified critical attributes to accurately describe PDX production and usage and proposed the PDX-Minimum information (PDX-MI) standard, which defines the minimal information for describing the clinical attributes of a patient’s tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use PDX models in cancer research. PDX-MI standard is the result of the collaborative work from more than 50 worldwide experts over 30 worldwide institutions.

本FAIRsharing记录介绍如下内容：患者来源肿瘤异种移植（Patient-derived tumor xenograft，PDX）小鼠模型是用于探究肿瘤演化、药物响应及个性化医疗策略的关键肿瘤学研究平台。本研究团队明确了可精准描述PDX构建与应用的核心属性，并提出了PDX最低信息标准（PDX-Minimum Information，PDX-MI）。该标准界定了描述患者肿瘤临床属性、肿瘤在宿主小鼠品系内的移植与传代流程、质量保证方法，以及PDX模型在癌症研究中应用方式的最低信息要求。PDX-MI标准系全球30余家机构的50余位专家协同合作的成果。