Supplementary Material for: Predictors of Very-Low-Energy Diet Outcome in Obese Women and Men

Objective: The aim of this study was to explore baseline outcome predictors of a 12-week very-low-energy diet (VLED) treatment. Methods: Obese patients (177 women and 90 men) started treatment. Multivariate linear and logistic regressions were used to predict weight loss (%), successful outcome (≧ 10% weight loss) and attrition. Potential predictors were anthropometry, socioeconomic variables, established questionnaires on health-related quality of life, and eating behavior, and additional questions related to dieting. Results: Mean weight loss was 13.5% (standard deviation (SD) 5.6) in women and 15.1% (6.1) in men (p = 0.054). Greater weight loss in women was predicted by having more children, lower education, and better perceived physical health (R-square (R2) = 12.7%), and in men by better ambulation capacity, living with a partner/children, and snacking on ice-cream more often (R2 = 39.4%). Successful outcome in women was predicted by less obesity-related psychosocial dysfunction, and in men by better functioning in social interaction and ambulation capacity. Attrition was predicted by lower age and larger hip circumference in women, and in men by lower perceived general health. Two-week weight loss was independently associated with all outcomes except attrition in women. Conclusion: Factors related to perceived physical health, social interaction, socio-economic factors, and obesity-related psychosocial problems predicted VLED outcome. The predictors differed by gender.

研究目的：本研究旨在探索12周极低能量饮食（very-low-energy diet, VLED）治疗的基线结局预测因子。研究方法：纳入177名女性、90名男性肥胖患者开展治疗，采用多元线性回归与logistic回归分别预测体重下降百分比、治疗成功结局（体重下降≥10%）以及脱落率。潜在预测因子涵盖人体测量学指标、社会经济变量、经验证的健康相关生存质量问卷、饮食行为问卷，以及与节食相关的补充问题。研究结果：女性患者的平均体重下降幅度为13.5%（标准差（standard deviation, SD）5.6），男性患者为15.1%（SD=6.1）（p=0.054）。对于女性患者，子女数量更多、受教育程度更低以及自我感知身体健康状况更佳可预测其更大的体重下降幅度（决定系数（R-square, R²）=12.7%）；对于男性患者，行走能力更佳、与伴侣/子女共同生活以及更频繁食用冰淇淋零食可预测其更大的体重下降幅度（R²=39.4%）。女性患者的治疗成功结局可通过更低的肥胖相关社会心理功能障碍预测，而男性患者的治疗成功结局则可通过更佳的社交互动功能与行走能力预测。女性患者的脱落率可通过更低的年龄与更大的臀围预测，男性患者的脱落率则可通过更差的自我感知总体健康状况预测。在女性患者中，两周后的体重下降量与除脱落率外的所有结局指标均存在独立关联。研究结论：与自我感知身体健康状况、社交互动、社会经济因素以及肥胖相关社会心理问题相关的因子，可预测极低能量饮食治疗的结局，且不同性别的预测因子存在差异。