IL-4 induced non-canonical trained immunity via epigenetic modification
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE196099
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资源简介：
The canonical role of IL-4 is to induce M2 macrophage polarization. Herein we report that in addition to its canonical role, IL-4 also induces non-canonical pro-inflammatory response via epigenetic memory. Although IL-4 stimulated macrophages do not produce classic proinflammatory cytokines such as IL-6 and IL-1β, they produce heightened proinflammatory cytokine upon LPS stimulation. BMDMs were isolated from bone marrow, treated with 20ng/ml IL4.
创建时间：
2023-08-06
