List of leading positions located in the 7-TMs of the ��2-AR and rhodopsin (Rho) that are in contact with the co-crystallized ligand (underlined) and/or qualified as leading positions (in bold and marked with an *).

The MI data refer to the analysis performed on the MSA of the 7-TMs class A receptors using Dunn, Wahl and Gloor's (2008) method [37] to obtain MIp the corrected MI. The position has highest MI (among all other inter-TM positions) with the listed pair position (pp). Rank is the MI ranking of that pair using the class A 7-TM MSA (287 sequences) and the degree is calculated using MIp graph from top 600 MIp pairs. Positions are not included in the MIp graph have ��n.a.�� ascribed to the degree value. Entropy and MI are measured in bits.