COX4I1

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

细胞色素c氧化酶（COX）是线粒体呼吸链的末端酶。它是一种多亚基酶复合体，将细胞色素c中的电子传递至分子氧，并有助于形成线粒体内膜的质子电化学梯度。该复合体由13个线粒体和核编码的亚基组成。线粒体编码的亚基执行电子传递和质子泵活动。核编码亚基的功能尚不明确，但它们可能在复合体的调节和组装中发挥作用。本基因编码人类线粒体呼吸链酶的核编码亚基IV型异构体1。该基因位于NOC4（COX4邻近基因）基因的3'端，呈首尾相接的排列，并与NOC4共享启动子。与该基因相关的假基因位于13号和14号染色体上。选择性剪接导致多种转录变体，这些变体编码不同的异构体。[由RefSeq提供，2016年1月]