APP processing landscape.

Pathway/processes identified as regulating each readout are listed (see supplementary information for full list) and organized based on cluster membership. Each cluster corresponds to pathway/processes sets that have a high degree of overlap (i.e. share common genes) (see Fig. 1B). Most of the pathway/processes listed here are consistent with factors known to play a role in the pathogenesis of Alzheimer’s disease (see supplementary information)[25]. Number of gene sets (pathways/processes) identified as significant for each readout at P S12 Supplementary Information). In bold are pathway/process sets that contain at least one gene (in parentheses) found to be significant in AD GWAS studies [21,22,25]. In italics correspond to pathways/processes directly associated with APP processing.APP processing landscape.