Effect of sleeve gastrectomy on lipid parameters and cardiometabolic risk in young women

ABSTRACT Objective: to analyze the effect of vertical gastrectomy on lipid profile and cardiometabolic risk in young women, preoperatively and 6 months after the operation. Methods: retrospective study, encompassing medical record reviews of women’s charts, preoperatively and in six months after the operation. Data collection was performed in the second half of 2015, using a review protocol with questions on the clinical-laboratory profile, anthropometric and laboratory classification of dyslipidemias. Descriptive and inferential analysis were used to treat the variables, using measures of variance, association and linear regression. Results: we analyzed medical records of 114 women undergoing vertical gastrectomy, with a mean age of 33.82±10.92, and with complete high school education. There was a significant reduction of anthropometric data, as well as serum lipid values, six months after the surgical procedure. The coefficients of determination and the results of linear regression, showed that the reduction in serum triglyceride values and increase in high-density lipoprotein have a direct impact on the reduction of the cardiometabolic risk. Regarding the laboratory classification of dyslipidemias, it was observed that the majority presented a significant reduction at the six-month follow-up. Mixed hyperlipidemia showed no significant reduction. The categorized cardiometabolic risk showed a significant reduction in women at risk before vertical gastrectomy. Conclusion: at the six-month follow-up, vertical gastrectomy was effective in reducing the serum lipid profile and the cardiometabolic risk of young women when compared to the preoperative data. There was also a different improvement in the laboratory classification of dyslipidemias at the six-month follow-up after the surgical procedure.

摘要
目的：探讨垂直袖状胃切除术(vertical gastrectomy)对年轻女性术前及术后6个月血脂谱与心血管代谢风险的影响。
方法：本研究为回顾性研究，通过回顾女性患者的病历资料，收集其术前及术后6个月的相关数据。数据采集工作于2015年下半年开展，采用标准化病历采集方案，采集内容涵盖临床实验室特征、人体测量学指标及血脂异常(dyslipidemias)的实验室分类指标。研究采用描述性统计与推断性统计方法处理变量，运用方差分析、相关性分析及线性回归模型开展数据分析。
结果：本研究共纳入114例行垂直袖状胃切除术的女性患者，平均年龄为33.82±10.92岁，均完成高中学业。术后6个月，患者的人体测量学指标及血清血脂水平均出现显著下降。线性回归的决定系数及分析结果显示，血清甘油三酯水平的降低与高密度脂蛋白(high-density lipoprotein)水平的升高，对心血管代谢风险的降低具有直接正向作用。针对血脂异常的实验室分类结果，多数患者在6个月随访期内血脂异常情况得到显著改善，但混合性高脂血症未出现明显缓解。术前存在心血管代谢风险的患者，其风险分级在术后出现显著降低。
结论：与术前基线数据相比，术后6个月随访时，垂直袖状胃切除术可有效降低年轻女性的血清血脂谱水平与心血管代谢风险。术后6个月随访时，患者血脂异常的实验室分类结果也呈现出不同程度的改善。