Heidelberg BAG (HeidelBAG)

The HeidelBAG unites macromolecular crystallography of EMBL Heidelberg and the Heidelberg University Biochemistry Center (BZH). Central to all projects are large assemblies involved in chromosome organization and transcription control, in nuclear and cytoplasmic RNA regulation and modification, in translational control by ribosome associated factors or further in protein targeting, membrane protein insertion or post-translational modification. While O. Barabas from EMBL has left the BAG, Svetlana Dodonova and Sebastian Eustermann at EMBL will join and add projects on chromatin organization. Nearly all projects make use of integrated structural biology techniques (MX, SAXS/SANS, NMR, cryo-EM, AI approaches) that are combined with complementary methods, a strategy that warranties the continuous success of the BAG. More and more the detailed architecture and mechanistic description of entire macromolecular machines come into focus. The BAG reports on 17 publications and 30 PDB entries.

海德堡大分子晶体学协作组（HeidelBAG）整合了欧洲分子生物学实验室（EMBL）海德堡分部与海德堡大学生物化学中心（BZH）的大分子晶体学研究力量。所有项目的核心均围绕参与染色体组织、转录调控、核质RNA调控与修饰、核糖体相关因子介导的翻译调控，以及蛋白质靶向、膜蛋白插入或翻译后修饰的大型复合物展开。尽管来自欧洲分子生物学实验室的O. Barabas已离开该协作组，但欧洲分子生物学实验室的Svetlana Dodonova与Sebastian Eustermann将加入团队，并新增染色质组织相关研究课题。几乎所有项目均采用整合结构生物学技术（MX、SAXS/SANS、NMR、冷冻电镜（cryo-EM）、人工智能方法），并结合互补实验手段，这一策略保障了该协作组的持续发展与成果产出。当前研究焦点愈发聚焦于完整大分子机器的精细结构与作用机制阐释。该协作组迄今已发表17篇学术论文，提交30条蛋白质数据库（PDB）条目。