Additional file 1 of Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

Additional file 1: Supplementary Tables. Table S1. Variant grouping strategies of 48 Interleukin-1 pathway related genes. Table S2. Molecular Inversion Probes (MIPs) covering all coding exons of 48 genes of the Interleukin-1 pathway. Table S3. Non-synonymous variant list. Table S4. Gene-level SKAT output. Table S5. Subpathway-level SKAT output. Table S6. Inflammatory-phenotype level SKAT output. Table S7. Validation SKAT output – permutations. Table S8. Synonymous variant list. Table S9. Validation SKAT output – synonymous. Table S10. Validation SKAT output – extreme outliers. Table S11. Common coding and non-coding IL38 set single SNP linear model parameters. Table S12. GWAS P-value versus SKAT adjP-value.

附加文件1：补充表格。表S1：48个白细胞介素-1（Interleukin-1）通路相关基因的变异分组策略。表S2：覆盖48个白细胞介素-1通路基因全部编码外显子的分子倒置探针（Molecular Inversion Probes，MIPs）。表S3：非同义变异列表。表S4：基因水平SKAT分析结果。表S5：亚通路水平SKAT分析结果。表S6：炎症表型水平SKAT分析结果。表S7：验证性SKAT分析结果——置换检验。表S8：同义变异列表。表S9：验证性SKAT分析结果——同义变异组。表S10：验证性SKAT分析结果——极端异常值组。表S11：常见编码与非编码IL38集合的单核苷酸多态性（Single Nucleotide Polymorphism，SNP）线性模型参数。表S12：全基因组关联分析（Genome-Wide Association Study，GWAS）P值与SKAT校正P值对比。