Estrogen-responsive BCL2 gene expression
收藏reactome.org2025-03-26 收录
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ESR1 and HIST1H2AC contribute to estrogen-responsive transcriptional activation at the BCL and MYC genes by promoting long-range chromatin loops between enhancer elements. This is accompanied by the recruitment of EP300 and RNA polymerase II (Su et al, 2014).
ESR1与HIST1H2AC通过促进增强子元件之间的长距离染色质环，共同参与了雌激素响应的转录激活作用，作用于BCL和MYC基因。此过程伴随着EP300和RNA聚合酶II的募集（Su等，2014年）。
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