Bulk RNA-sequencing of soft tissue sarcomas from patients undergoing chemotherapy and/or immunotherapy

The tumor microenvironment plays a crucial role in soft tissue sarcoma development and response to therapy. We performed bulk RNA-sequencing of tumors from patients with soft tissue sarcomas undergoing chemotherapy and/or immunotherapy to identify gene expression signatures associated with response to treatment. Overall design: Bulk RNA-sequencing was performed on 87 soft tissue sarcoma specimens from 54 patients. T1 is timepoint 1, and T2 is a later timepoint. An "a" or "b" from the same timepoint represent different regions.