Supporting data for "smart self-assembled nanoparticles for the treatment of age-related macular degeneration"

The thesis project aims to develop stimuli-responsive nanoparticles by self-assembling prodrugs for minimally invasive administration of age-related macular degeneration, including designing reactive oxygen species (ROS)-responsive prodrug nanoparticles and photoactivatable prodrug nanoparticles. The methods include the synthesis and characterization of stimuli-responsive prodrugs, the characterization of formulations, in vitro data of anti-angiogenic assays, and in vivo therapeutic and biosafety data in choroidal neovascularization mouse models.<br>

本学位论文研究旨在通过前药自组装技术开发刺激响应型纳米颗粒，用于年龄相关性黄斑变性的微创给药，具体包括设计活性氧（ROS）响应型前药纳米颗粒与光激活型前药纳米颗粒。研究方法涵盖刺激响应型前药的合成与表征、制剂表征、抗血管生成实验的体外数据，以及脉络膜新生血管小鼠模型中的体内治疗与生物安全性数据。