Intraocular pressure and central corneal thickness in full-term newborns

ABSTRACT Objective: The aim of this study was to determine the central corneal thickness (CCT) and intraocular pressure (IOP) in full-term newborns and to correlate these values with the following variables: weight, sex, and post-conception age (PCA). Methods: IOP and CCT were determined in 52 full-term newborns with a mean gestational age of 39.43 ± 1.03 weeks and a mean birth weight of 3,273 ± 558 g. The mean age of the neonates at the time of taking the measurements was 1.15 ± 1.38 days after birth. IOP was determined with a Tono-Pen, and CCT was determined using a handheld ultrasound pachymeter. Results: The mean overall IOP was 14.0 ± 2.91 mmHg, and the mean IOP in male and female newborns was 13.77 ± 2.88 mmHg and 14.32 ± 3.05 mmHg, respectively. The mean overall CCT was 605.87 ± 62.98 µm, and the mean CCT in male and female newborns was 626.70 ± 67.46 µm and 577.45 ± 45.50 µm, respectively; the mean CCT was higher in male newborns than in female newborns. PCA was negatively associated with CCT, IOP, and weight; however, only the correlation with CCT was statistically significant. Comparisons between the sexes showed significant differences for two variables: weight and CCT. Conclusions: No relationship was found between CCT and IOP; however, we found a positive association between weight and CCT.

摘要
研究目的：本研究旨在测定足月新生儿的中央角膜厚度（central corneal thickness, CCT）与眼压（intraocular pressure, IOP），并将上述指标与体重、性别及受孕后龄（post-conception age, PCA）等变量进行相关性分析。
研究方法：本研究纳入52例足月新生儿，其平均胎龄为39.43±1.03周，平均出生体重为3273±558g，测量时新生儿的平均出生后年龄为1.15±1.38天。采用Tono-Pen眼压计测定眼压，使用手持式超声角膜测厚仪测量中央角膜厚度。
研究结果：总体平均眼压为14.0±2.91 mmHg，其中男性新生儿平均眼压为13.77±2.88 mmHg，女性新生儿为14.32±3.05 mmHg。总体平均中央角膜厚度为605.87±62.98 µm，男性新生儿平均中央角膜厚度为626.70±67.46 µm，女性新生儿为577.45±45.50 µm，男性新生儿的中央角膜厚度高于女性新生儿。受孕后龄与中央角膜厚度、眼压及体重呈负相关，但仅与中央角膜厚度的相关性具有统计学意义。性别组间对比显示，体重与中央角膜厚度两个变量存在显著组间差异。
研究结论：本研究未发现中央角膜厚度与眼压之间存在关联，但发现体重与中央角膜厚度呈正相关。