Proteomics Data for "Streptozotocin induced diabetes augments expression of renal cell surface proteins and induces hypertension in cathepsin B knockout mice"

Cathepsin B (CtsB) plays a role in several biological processes in physiology and pathophysiology. Streptozotocin (STZ) treatment causes pancreatic beta cell distruction and type 1 diabetes in rodents. Here, we hypothesized STZ induces kidney damage, hypertension, and changes in expression of renal epithelial cell surface proteins independent of CtsB expression. In CtsB knockout mice, STZ treatment induced kidney damage, hypertension, and down-regulation of NPR-B and NPR-C protiens, presumably in part by causing a rearrangement of the actin cyctoskeleton in renal epithelial cells. These results suggest the expression of CtsB is not essential for the development of kidney damage, hypertension and reorganization of the actin cyctoskeleton in kidney.