Hepatitis E seroprevalence and associated risk factors in Croatian liver transplant recipients

Abstract INTRODUCTION Solid-organ transplant recipients are at risk of hepatitis E virus (HEV) infection. We analyzed the seroprevalence/risk factors of HEV in Croatian liver transplant recipients. METHODS Two hundred forty-two serum samples were tested for HEV immunoglobuline IgG/IgM and HEV RNA. Sociodemographic data and risk factors were collected using a questionnaire. RESULTS HEV IgG seroprevalence rate was 24.4%. Positive/equivocal HEV IgM were found in two patients. HEV RNA was not detected. Logistic regression showed that older age, female gender, rural area/farm, water well, and septic tank were associated with HEV seropositivity. CONCLUSIONS This study revealed a high exposure rate to HEV in Croatian liver recipients.

摘要

引言：实体器官移植受者存在感染戊型肝炎病毒（hepatitis E virus, HEV）的风险。本研究针对克罗地亚肝移植受者的HEV血清阳性率及相关危险因素展开分析。

方法：共采集242份血清样本，检测其中HEV免疫球蛋白IgG/IgM及HEV RNA；通过问卷调查收集社会人口学资料与危险因素相关数据。

结果：HEV IgG血清阳性率为24.4%；2例患者的HEV IgM检测结果呈阳性或可疑阳性，未检测到HEV RNA。Logistic回归分析显示，年龄较大、女性性别、农村地区/农场居住史、饮用井水以及使用化粪池与HEV血清阳性显著相关。

结论：本研究揭示克罗地亚肝移植受者的HEV暴露率较高。