Activation of highly calcium permeable nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors are activated upon ligand binding which opens the acetylcholine channels and permits Ca2+ and Na+ ion influx depending on the subunit composition and stoichiometry of the subunits. The ratio of Ca2+ to Na+ ion influx varies making the receptors either highly Na+ permeable or Ca2+ permeable.

尼古丁乙酰胆碱受体在配体结合后激活，从而开启乙酰胆碱通道，并允许钙离子（Ca2+）和钠离子（Na+）的流入，其流入比例取决于亚基组成和化学计量比。钙离子与钠离子的流入比例各异，使得受体要么具有较高的钠离子通透性，要么具有较高的钙离子通透性。