Foxp3-deficient Treg cells do not revert into conventional Effector CD4+ T cells but constitute a unique cell subset. Mus musculus

Gene expression profiles were compared between regulatory T cells (Treg) and Effector CD4+ T cells in healthy B6 mice and sick mice with scurfy mutation. We used microarrays to elucidate the molecular mechanisms underlying the suppression function of the Treg cells. Keywords: Cell type comparison Overall design: To identify candidate genes that might be related to the suppressive activity, the Treg cells expressing functional and mutant Foxp3 transcription factor were compared