Effect of CWG-cPIP on transcriptome defects in CUG mouse brain

CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate effects of CWG-cPIP on transcriptome defects in the brain of CUG300 mice, which we developed as a model of DM1, CWG-cPIP (83 ug/kg) was injected into mouse hippocampus. RNA sequencing analysis was performed using mouse hippocampus 10 days later. Overall design: Gene expression of RNA sequencing data for the mouse hippocampus. The groups consist of 1) CUG10 + vehicle (n = 3 mice); 2) CUG300 + vehicle (n = 3 mice); 3) CUG300 + CWG-cPIP (n = 3 mice).