Binding of IRS to insulin receptor

Using receptor mutagenesis studies it is known that IRS1 via its PTB domain binds to the insulin receptor at the juxtamembrane region at tyrosine 972. The interaction is further stabilized by the PH domain of IRS1 which interacts with the phospholipids of the plasma membrane. This allows the receptor to phosphorylate IRS1 on up to 13 of its tyrosine residues (Tavare and Denton 1998, Duan et al.2004).

通过受体的诱变研究，已知胰岛素受体底物1（IRS1）通过其PTB结构域与胰岛素受体在膜外区段的酪氨酸972位点结合。此相互作用进一步通过IRS1的PH结构域与质膜中的磷脂相互作用而得到稳定。这一过程使得受体能够在IRS1的13个酪氨酸残基上对其进行磷酸化，相关研究可参考Tavare和Denton（1998年）以及Duan等人（2004年）的工作。