RNA sequencing of hippocampal sample from normal male mice, stress induced depressive male mice and male offspring born to stress-induced depressed male mice

We demonstrated that the offspring of depressed fathers display reduced resilience to stress and enhanced susceptibility to depression. To explain the observed behavioural phenotypes of depression in offspring produced by depressed fathers, molecular profiling was performed in key brain regions.We examined the hippocampal sample from normal male mice, stress induced depressive male mice and male offspring born to stress-induced depressed male mice by RNA sequencing. Overall design: Hippocampal samples collected from 3 independent male mice of normal (F0-Ctl), stress induced depressive (F0-Dep) and offspring born to normale male mice (F1-Ctl) or stress-induced depressed male mice (F1-Dep) groups were processed for RNA extraction.