Gene expression study of macrophages during early foreign body reaction

Searching for mechanisms potentially useful to overcome these complications, we have established the signaling role of macrophages in the development of FBR. This study profiles gene expression of in vitro fibrinogen activated macrophages as well as that of freshly isolated macrophages from 3-days implants, against a background of unactivated macrophages/monocytes.为探寻可有效克服此类并发症的潜在机制，我们明确了巨噬细胞（macrophages）在异物反应（Foreign Body Reaction，FBR）发生发展中的信号调控作用。本研究以未激活巨噬细胞/单核细胞为参照，对体外纤维蛋白原（fibrinogen）激活的巨噬细胞及从植入后3天的植入物中新鲜分离的巨噬细胞开展基因表达谱分析。