Applying transcriptomics to screen the significantly altered genes, cell function and signal transduction pathway of chicken trachea exposured to hydrogen sulfide

Hydrogen sulfide (H2S) is well known to cause irritation and damage to airway following inhalation, but the mechanism by which H2S contributes to airway toxicity is unclear. We apply transcriptomics to demonstrate the possible effects, obtain valuable information about adverse health effects following H2S exposure and to study the molecular mechanisms of the gas toxicity in trachea. Overall design: lncRNA and miRNA profiles of 42-day old normal and hydrogen sulfide exposed chicken were generated by deep sequencing, in triplicate.