The CGG KI Mouse Model does not show Learning and Memory Deficits on the Water maze or Motor Deficits on the Rotarod

In this study, CGG KI mice modeling the fragile X premutation were tested on the Morris water maze. There were no group differences among mutant mice and littermate controls during acquisition and the probe trial. Neither were there deficits for motor learning on the accelerating rotarod. Importantly, these same mice shows deficits for fine spatial processing using more sensitive behavioral assays (<em>Hunsaker MR, et al. Progressive spatial processing deficits in a mouse model of the fragile X premutation. Behav Neurosci. 2009 Dec;123(6):1315-24. doi: 10.1037/a0017616. PubMed PMID: 20001115; PubMed Central PMCID: PMC3410547</em>)

本研究中，我们对构建脆性X前突变模型的CGG KI小鼠开展了莫里斯水迷宫（Morris water maze）行为学检测。在习得训练与探查测试阶段，突变型小鼠与同窝对照小鼠之间未出现显著组别差异。加速旋转棒实验中，小鼠的运动学习能力亦未表现出缺陷。值得注意的是，采用更灵敏的行为学检测方法时，这批小鼠表现出精细空间加工能力的缺陷(<em>Hunsaker MR 等. 脆性X前突变小鼠模型的进行性空间加工缺陷. 行为神经科学（Behav Neurosci）. 2009年12月；123(6)：1315-24. DOI: 10.1037/a0017616. PubMed PMID: 20001115; PubMed Central PMCID: PMC3410547</em>)