IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2498 proposal and can be grouped into different topics as follows: host-pathogen interaction, new therapy targets, fundamental cellular mechanisms, membrane proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, cryo-EM, SAXS and NMR), together with other biophysical and biochemical studies, and very recently the use of AI, with the aim to fully understand the complexity of the biological macromolecular systems under study.

本提案中的IBS BAG涵盖IBS内部团队以及来自CEA-Cadarache（圣保罗勒兹迪朗斯）与IRBA（奥尔日河畔布雷蒂尼）的外部合作群组。本研究聚焦蛋白质的结构-功能关联，重点覆盖人类健康、生物技术与研究方法学三大方向。本项目绝大多数为MX-2498提案的延续，可归类为以下若干研究主题：宿主-病原体互作、新型治疗靶点、基础细胞机制、膜蛋白、生物技术应用及研究方法学。部分项目采用整合研究策略，联合应用X射线晶体学、冷冻电子显微镜（cryo-EM）、小角X射线散射（SAXS）与核磁共振（NMR）等技术，并辅以其他生物物理、生物化学研究手段；近期还引入了人工智能（Artificial Intelligence，AI）技术，旨在全面解析所研究的生物大分子系统的复杂性。