The relationship of neutrophil to lymphocyte ratio with testicular cancer

ABSTRACT Purpose: To assess the relationship between testicular germ cell tumors (TGCT) and neutrophil to lymphocyte ratio (NLR) and to determine whether this ratio can be used as a serum tumor marker. Material and Methods: Sixty-one patients with testicular germ cell tumors were included into the study. Patients were grouped as localized and non-localized. Histologically patients were categorized as seminoma and nonseminomatous germ cell tumors. Complete blood cell count was measured the day before surgery and at the postoperative 1st month. Preoperative and postoperative mean NLR values were compared. Results: Thirty-six patients (59%) had seminomas and 25 patients (41%) had nonseminomatous testicular cancer. Forty-five patients (73.8%) had localized and 16 patients (26.2%) had non-localized testicular cancer. There was a statistically significant difference between preoperative and postoperative mean NLR of the localized patients (p=0.001) but no such difference was detected for non-localized patients (p=0.576). Nineteen patients with localized seminomas had normal preoperative serum tumor markers. There was a significant difference between preoperative and postoperative mean NLR in this group of patients (p=0.010). Twenty-six patients with localized tumors had preoperative increased serum tumor markers which normalized after orchiectomy. Mean NLR of these patients significantly decreased from 3.10±2.13 to 1.62±0.59 postoperatively (p=0.010). Conclusions: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early postoperative period.

摘要
研究目的：本研究旨在评估睾丸生殖细胞肿瘤（testicular germ cell tumors, TGCT）与中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio, NLR）之间的关联，并明确该比值是否可作为血清肿瘤标志物使用。
材料与方法：本研究纳入61例睾丸生殖细胞肿瘤患者，将患者分为局限性与非局限性两组。根据组织学类型，将患者划分为精原细胞瘤与非精原细胞瘤性生殖细胞肿瘤两类。分别于术前1日及术后1个月检测患者全血细胞计数，对比术前与术后的平均中性粒细胞与淋巴细胞比值。
结果：本研究中，36例（59%）患者为精原细胞瘤，25例（41%）为非精原细胞瘤性睾丸癌；45例（73.8%）为局限性睾丸癌，16例（26.2%）为非局限性睾丸癌。局限性患者的术前与术后平均中性粒细胞与淋巴细胞比值存在统计学显著差异（p=0.001），而非局限性患者未观察到此类差异（p=0.576）。19例局限性精原细胞瘤患者术前血清肿瘤标志物水平正常，该组患者的术前与术后平均中性粒细胞与淋巴细胞比值存在显著差异（p=0.010）。26例局限性肿瘤患者术前血清肿瘤标志物水平升高，经睾丸切除术后恢复正常，此类患者的平均中性粒细胞与淋巴细胞比值从术前的3.10±2.13显著降至术后的1.62±0.59（p=0.010）。
结论：中性粒细胞与淋巴细胞比值可作为睾丸生殖细胞肿瘤的有效标志物，在术后早期可有效区分局限性与非局限性病变。