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Dissecting cell composition and cell-cell interaction network of human disease heart tissue by single-cell sequencing

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121893
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We studied the cell compositon of two types of human heart disease (coronary atherosclerotic heart disease and dilated cardiomyopathy) by single-cell sequencing. Distinct subgroups of cardiac muscle, fibroblast cell and endothelial cell were detected. We generated a cell-cell interaction network using specific expressed ligands and receptors of cells. And we also observed the change of interaction and cell transformation with age. Extract cells from left ateria and ventricle of human heart tissue and conduct single-cell sequencing
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2020-05-28
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