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Structure of KIT V654A mutant with Compound 11

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Protein Data Bank Japan2026-05-06 更新2026-04-19 收录
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Structure of KIT V654A mutant with Compound 11 Descriptor: 1,2-ETHANEDIOL, 6-[(6-amino-2-cyclopropylpyrimidin-4-yl)amino]-N-methyl-4-[(propan-2-yl)amino]pyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... Authors: Kim, J.L. Deposit date: 2025-11-05 Release date: 2026-03-18 Last modified: 2026-05-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Design and Synthesis of BLU-654, a Potent and Selective Mutant KIT V654A Inhibitor for the Treatment of Imatinib-Resistant GIST. J.Med.Chem., 69, 2026
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2025-11-05
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