Logistic regression analysis for genotype-wise associations between ABCA4 and COL2A1 and risk of congenital toxoplasmosis in the EMSCOT mother-child pairs.

Results are for genotype associations comparing affected children against unaffected children from infected mothers, and mothers of affected children against mothers of unaffected children. OR = odds ratio; CI = confidence intervals; P = probability. Bold indicates significant at P��0.05.aSignificant genotype-wise associations observed for mothers of children with brain lesions but no eye lesions followed the same pattern with significant protection in heterozygous mothers of affected children (data not shown). All analyses were adjusted for country of birth, trimester of seroconversion, and country of origin of grandparents as a surrogate for ethnicity. Table S8 provides full details of the numbers of children and mothers (respectively) carrying each genotype for each phenotypic group.