Effect of muscle-specific ATF4 gene knockout (ATF4 mKO) on skeletal muscle mRNA levels in aged mice

For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Quadriceps femoris muscles were harvested from 22-month-old muscle-specfic ATF4 knockout (ATF4 mKO) mice and littermate controls. mRNA levels in ATF4 mKO muscles were normalized to levels in littermate control muscles.如需获取更多详细信息，请参阅Ebert等人发表的《激活转录因子4（ATF4）依赖性通路的鉴定及其小分子抑制：靶向年龄相关性骨骼肌衰弱与萎缩》。 研究人员采集了22月龄的肌肉特异性ATF4敲除（ATF4 mKO）小鼠及其同窝对照小鼠的股四头肌组织。 ATF4 mKO小鼠骨骼肌中的信使RNA（mRNA）水平以同窝对照小鼠骨骼肌的mRNA水平为基准进行标准化处理。