Supplementary data 4. The interaction partners of the NAFLD-candidate genes from the liver-specific PPIN, their pathway enrichment result and the trait enrichment results of the eQTLs regulating them

The proteins directly interacting with the proteins encoded by NAFLD-candidate genes were identified from the liver-specific protein-protein interaction network (PPIN). The interacting partners were significantly enriched within biological pathways related to cancers and NAFLD pathogenesis. The eQTLs regulating the interacting partners were enriched for GWAS traits including those that were previously linked to or multimorbid with NAFLD.

从肝脏特异性蛋白质相互作用网络（Protein-Protein Interaction Network，PPIN）中，鉴定得到非酒精性脂肪性肝病（Non-Alcoholic Fatty Liver Disease，NAFLD）候选基因编码蛋白的直接相互作用蛋白。该类相互作用伴侣蛋白在与癌症及NAFLD发病机制相关的生物学通路中显著富集。调控该类相互作用伴侣蛋白的表达数量性状位点（expression Quantitative Trait Locus，eQTL），在全基因组关联研究（Genome-Wide Association Study，GWAS）的相关性状中存在富集，这些性状涵盖此前已被报道与NAFLD相关或与其存在共病关联的表型。