The Israeli BAG

The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

该BAG数据集规模庞大，共汇聚24位首席研究员，其研究团队几乎覆盖以色列境内所有相关研究群组。其涵盖的科学主题纷繁多元，短篇幅摘要难以完整呈现所有研究方向。在此背景下，BAG成员正围绕多项核心课题开展研究：包括调控蛋白质组装的各类参数，以及不同信号级联反应中信号传导过程的结构影响。另有多项研究聚焦分子识别，并将相关成果应用于药物设计领域。此外，团队还推进了核糖体（ribosome）相关研究，针对霉素霉素（mycinamycins）家族中具有特异性功能相互作用的独特抗生素进行设计，同时探究该类抗生素相较于其他大环内酯类（macrolides）药物的耐药相关机制，以及光系统（photosystem）将光能转化为能量的作用机制。鉴于新型冠状病毒肺炎（COVID-19）与其他病毒感染仍是当前的研究热点，BAG成员长期以来始终致力于解析病毒感染过程，并探索抑制感染的有效手段。