Genome-wide burden of STR mutations.

For each class of STR (repeat unit sequence/optimal [modal] allele combination), the table shows the number of loci, mean burden of each new mutation computed as the selection coefficient for that class times the mean mutation size, the scaled mean burden of each new mutation (where the original value is divided by 2), mutation rate for that class, and total estimated burden contributed by each class. Burden is computed as 2*mutation rate*mean scaled burden*number of loci. The KS Score is the same one presented in S2 Table and is used to filter out loci for the burden analysis where the mutational model did not fit well. Only loci with scores >50 were retained. The number of mutations/category reflects 2*mutation rate*number of loci in the category. The column “mean burden/mutation (rescaled) x number of loci” reflects the mean rescaled burden multiplied by the number of loci, which is then used to estimate the mean rescaled s shown in Table 1. (XLSX)