Gene expression data from THP-1 cells expressing RKIP shRNA vs control. Homo sapiens

Myeloid sarcoma (MS) is a subform of acute myeloid leukemia (AML), where myeloid blasts infilitrate extramedullary tissues, a process that resembles the formation of metastases in solid tumors. RKIP has been shown to be a metastasis-suppressor gene. Identification of genes modulated by RKIP in human AML cells helps us to identify mechanisms how RKIP could be involved in the formation of MS. Overall design: Total RNAs were extracted from THP-1 cells expressing RKIP shRNA and vector control. Affymetrix Human Gene 2.0 ST mRNA Arrays were performed to assess the gene expression and to identify the genes regulated by RKIP knockdown in human acute myeloid leukemia cells.