Comparing Itch in Psoriasis, Atopic Dermatitis, and Chronic Idiopathic Urticaria: A Meta-Analysis

Although psoriasis has anecdotally been perceived as less itchy than atopic dermatitis (AD) and chronic idiopathic urticaria (CIU), previous studies have not directly compared this, nor the potential correlation between itch and disease response in clinical trials. We conducted a systematic review of phase 2/3 randomized controlled trials to compare baseline itch severity in psoriasis, AD, and CIU, using data from PubMed up to September 2022. 52 studies were included in the final analysis (33 AD, 15 psoriasis, 5 CIU). All itch scores were adjusted to a 100-point scale for comparison. Mean baseline itch scores and mean itch per body surface area scores were calculated across disease indications. Objective disease response and itch improvement were also calculated across AD and psoriasis trials according to different systemic therapies administered.

尽管坊间普遍认为银屑病（Psoriasis）的瘙痒程度轻于特应性皮炎（Atopic Dermatitis, AD）与慢性自发性荨麻疹（Chronic Idiopathic Urticaria, CIU），但既往研究尚未直接比较这一差异，亦未探讨临床试验中瘙痒与疾病应答之间的潜在关联。本研究基于截至2022年9月PubMed数据库收录的文献数据，针对Ⅱ/Ⅲ期随机对照试验开展系统综述，以比较银屑病、特应性皮炎与慢性自发性荨麻疹患者的基线瘙痒严重程度。最终纳入52项研究进行分析，其中特应性皮炎相关研究33项、银屑病相关研究15项、慢性自发性荨麻疹相关研究5项。为确保跨疾病人群的比较一致性，所有瘙痒评分均被标准化至100分制量表。研究人员针对不同疾病人群，分别计算了其基线瘙痒平均评分与每体表面积平均瘙痒评分。同时，本研究还依据所采用的不同系统性治疗方案，分别分析了特应性皮炎与银屑病试验中的客观疾病应答及瘙痒改善情况。