Expression and Prognostic impact of LncRNAs in Acute Myeloid Leukemia

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To determine whether lncRNAs are associated with clinical features and recurrent mutations in older patients (aged ≥60 years) with cytogenetically normal (CN) acute myeloid leukemia (AML), we evaluated lncRNA expression in 148 untreated older CN-AML cases using a custom microarray platform.

长链非编码RNA（long noncoding RNAs，lncRNAs）是一类长度超过200个核苷酸的转录本，可定位于蛋白编码基因的基因间区域或与其重叠的反义转录本中。长链非编码RNA参与诸多生物学功能，包括印记调控、表观遗传调控、细胞凋亡与细胞周期调控。为明确长链非编码RNA是否与细胞遗传学正常（cytogenetically normal，CN）急性髓系白血病（acute myeloid leukemia，AML）老年患者（年龄≥60岁）的临床特征及复发性突变相关，本研究采用定制微阵列平台，对148例初治老年CN-AML患者的lncRNA表达水平进行了检测分析。