A small Jointly profiled 10X Genomics ATAC+GEX dataset on Human PBMCs

we will guide you through the process of inferring enhancer regulons, known as eRegulons, and enhancer-driven gene regulatory networks or eGRNs, utilizing the STREAM tool. Our demonstration leverages a select subset of data from the publicly accessible 10x Genomics Multiome dataset, specifically focusing on human Peripheral Blood Mononuclear Cells (PBMCs). For those interested in the comprehensive dataset, the raw data captured by the 10X Genomics Multiome ATAC+GEX can be downloaded directly from https://www.10xgenomics.com/resources/datasets/pbmc-from-a-healthy-donor-granulocytes-removed-through-cell-sorting-10-k-1-standard-1-0-0.

本指南将指导您完成利用STREAM工具推断增强子调控子（enhancer regulons，简称eRegulons）以及增强子驱动的基因调控网络（enhancer-driven gene regulatory networks，简称eGRNs）的完整流程。本次演示采用了公开可用的10x基因组学（10x Genomics）多组学数据集的精选子集，研究聚焦于人类外周血单个核细胞（Peripheral Blood Mononuclear Cells，简称PBMCs）。若您希望获取完整数据集，可直接从以下链接下载由10x基因组学多组学ATAC+GEX采集的原始数据：https://www.10xgenomics.com/resources/datasets/pbmc-from-a-healthy-donor-granulocytes-removed-through-cell-sorting-10-k-1-standard-1-0-0。