The lineage-specific transcriptional regulator, CDX2, navigates a dynamic chromatin landscape to control distinct stages of intestinal development

Important lineage regulators, such as the intestinal lineage regulator CDX2, can function over the timespan of intestinal development. The consequences of CDX2 knockout in the embryo versus in the adult are quite distinct. The data below provide a rationale for these divergent transcription factor functions in distinct developmental contexts, with unique binding patterns of CDX2 observed via ChIP-seq and unique gene regulatory targets defined via RNA-seq. The dynamic gene regulatory program controlled by CDX2 is conserved in mice and humans. CDX2 ChIP-seq and RNA-seq experiments were conducted at various stages of mouse or human iPSC-derived tissues or primary adult human tissues.