Swiss consortium in macromolecular X-ray crystallography structure determination for academic researchers: EPFL, UNIL, UNIGE and SLS-MX joi

This proposal is a joined application by major swiss academic universities; EPFL, UNIL, UNIGE and SLS-MX; and lead by Dr. Florence Pojer, head of the protein Production and Structure core facility at EPFL, an expert in X-ray crystallography with over 20 years experience. The applicants are regular users of the MX beamlines at the Swiss Light Source at PSI. As SLS-PSI will close its door in summer 2023 for 2 years, It is now essential for our community to collect data at ESRF. Moreover, the access to the automated MASSIF-1 beamline, managed by Didier Nurizzo and colleagues, will be an amazing value to our current pipeline. A non exhaustive list of projects by the applicants is presented below. The consortium will need around 14 shifts per 6 months, similar to what they currently are allocated at PSI-SLS. Important note; no application was sent to other synchrotron sources.

本提案由瑞士主要学术高校及团队联合提交，包括洛桑联邦理工学院（EPFL）、洛桑大学（UNIL）、日内瓦大学（UNIGE）与SLS-MX团队，由弗洛伦斯·波杰（Florence Pojer）博士牵头；波杰博士现任EPFL蛋白质生产与结构核心设施负责人，是拥有20余年从业经验的X射线晶体学专家。申请人均为保罗谢尔研究所（PSI）旗下瑞士光源（SLS）大分子晶体学（MX）线站的常规用户。鉴于PSI-SLS将于2023年夏季关停两年，本科研共同体亟需前往欧洲同步辐射光源（ESRF）开展数据采集工作。此外，获取由迪迪埃·努里佐（Didier Nurizzo）及其团队运维的自动化MASSIF-1线站的使用权限，将对我们当前的科研管线带来极大增益。下文列出申请人所参与项目的非详尽清单。该科研联合体每6个月约需14个机时段，与他们目前在PSI-SLS获得的机时分配额度相当。重要说明：本申请未向其他同步辐射光源提交。