伏隔核单细胞连接谱
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伏隔核协调着包括奖赏与动机在内的一系列关键生理功能，但其输入与投射的组织原则尚未明确。本研究系统考察了伏隔核中等棘神经元输入与投射的组织规律。结果显示，SI亚区中神经元胞体及其末梢呈现拓扑分布特征。狂犬病毒追踪技术揭示，Tac2（D1亚型）神经元与Calcr神经元在伏隔核各亚区接收的单突触输入存在显著差异。进一步研究发现，皮层→伏隔核投射神经元依据不同的皮层起源与侧支分化特征，优先靶向伏隔核核心区或壳区。海马→伏隔核投射神经元则主要支配核心区与内侧壳区，呈现纵向拓扑分布特征，且与下丘脑的协同投射最为显著。这些研究结果系统解析了伏隔核特定细胞类型在不同亚区的神经连接模式，为深入理解伏隔核功能特化的神经环路机制提供了结构基础。
The nucleus accumbens (NAc) coordinates a series of critical physiological functions including reward and motivation, yet the organizational principles of its inputs and projections remain unclear. This study systematically investigated the organizational rules governing inputs and projections of medium spiny neurons (MSNs) in the nucleus accumbens. The results revealed that neuronal somata and their terminals in the SI subregion exhibit topological distribution characteristics. Retrograde rabies virus tracing technology revealed that Tac2-expressing (D1 subtype) neurons and Calcr-expressing neurons exhibit significant differences in their monosynaptic inputs across all subregions of the nucleus accumbens. Further investigations found that cortical-to-nucleus accumbens projection neurons preferentially target either the core or shell subregions of the nucleus accumbens, depending on their cortical origins and collateral differentiation characteristics. In contrast, hippocampus-to-nucleus accumbens projection neurons primarily innervate the core and medial shell subregions, displaying longitudinal topological distribution characteristics, and their coordinated projections with the hypothalamus are the most prominent. These findings systematically elucidate the neural connection patterns of specific cell types in the nucleus accumbens across different subregions, providing a structural foundation for in-depth understanding of the neural circuit mechanisms underlying the functional specialization of the nucleus accumbens.
