MOESM2 of Values of integration between lipidomics and clinical phenomes in patients with acute lung infection, pulmonary embolism, or acute exacerbation of chronic pulmonary diseases: a preliminary study

Additional file 2: Figure S1. The map of lipidomic profiles of healthy control or patients with severe acute pneumonia, acute pulmonary embolism, or acute exacerbation of chronic pulmonary diseases. The average levels of 502 lipid elements were used and scattered from blue to red colors, indicating levels of lipid elements changes from low to high. Figure S2. Top 6 of the highest values of lipid elements were selected from healthy patients or patients with control, with severe acute pneumonia (SAP), acute pulmonary embolism (APE), or acute exacerbation of chronic pulmonary diseases (AECOPD). Those top 6 elements selected are independent upon statistical significance, different from Figure S4. Figure S3. The ROC curve of up-regulated lipid elements in severe acute pneumonia with statistical significance. Figure S4. The ROC curve of up-regulated lipid elements in acute pulmonary embolism with statistical significance. Figure S5. The ROC curve of up-regulated lipid elements in acute exacerbation of chronic pulmonary diseases with statistical significance. Figure S6. The ROC curve of down-regulated lipid elements in severe acute pneumonia, acute pulmonary embolism, or acute exacerbation of chronic pulmonary diseases with statistical significance.

附加文件2：图S1。健康对照者、重症急性肺炎（severe acute pneumonia, SAP）、急性肺栓塞（acute pulmonary embolism, APE）或慢性肺部疾病急性加重（acute exacerbation of chronic pulmonary diseases, AECOPD）患者的脂质组学特征图谱。本研究采用502种脂质成分的平均水平，以从蓝色至红色的渐变色彩表征脂质成分的表达水平由低到高的变化。
图S2。从健康对照者、重症急性肺炎（SAP）、急性肺栓塞（APE）或慢性肺部疾病急性加重（AECOPD）患者中选取数值最高的前6项脂质成分。所选的这6项成分与统计学显著性无关，与图S4存在差异。
图S3。经统计学验证的重症急性肺炎患者上调脂质成分的受试者工作特征（Receiver Operating Characteristic, ROC）曲线。
图S4。经统计学验证的急性肺栓塞患者上调脂质成分的ROC曲线。
图S5。经统计学验证的慢性肺部疾病急性加重患者上调脂质成分的ROC曲线。
图S6。经统计学验证的重症急性肺炎、急性肺栓塞或慢性肺部疾病急性加重患者下调脂质成分的ROC曲线。